Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones
نویسندگان
چکیده
منابع مشابه
CuO-CeO2 nanocomposite: A green recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
CuO-CeO2 nanocomposite is reported as a green and highly efficient recyclable catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The catalyst was synthesized by co-precipitation method and characterized by XRD, BET specific surface area, FESEM and EDS analysis.
متن کاملThree Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst
Synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives from aldehydes, 1,3-dicarbonyl derivatives and urea or thiourea using granite and quartz as new, natural and reusable catalysts. Some of the 3,4-dihydropyrimidin-2(1H)-thione derivatives were used to prepare new heterocyclic compounds. The antimicrobial activity of selected examples of the synthesized ...
متن کاملSbCl5.SiO2: an reusable lewis acid for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones)
Nano-SbCl5.SiO2 and SbCl5.SiO2 are bench-top catalysts which are reusable, readily available, versatile andefficient for promotion of many acid catalyzed organic reactions. These catalysts do not need specialprecautions for preparation, handling or storage, and they can be stored at an ambient temperature for monthswithout losing their catalytic activity. 4-dihydropyrimidin-2(1H)-ones(thiones) ...
متن کاملCuO-CeO2 nanocomposite: A green recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
CuO-CeO2 nanocomposite is reported as a green and highly efficient recyclable catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The catalyst was synthesized by co-precipitation method and characterized by XRD, BET specific surface area, FESEM and EDS analysis.
متن کاملA rapid and convenient synthesis of 5-unsubstituted 3,4-dihydropyrimidin- 2-ones and thiones
A rapid and convenient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2-ones and thiones was developed. The reaction involves a one-pot reaction between oxalacetic acid, thiourea/urea, and aldehyde under microwave irradiation and provides the products in good yields and much shorter reaction times. 2010 Elsevier Ltd. All rights reserved.
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ژورنال
عنوان ژورنال: Arabian Journal of Chemistry
سال: 2019
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2016.12.007